Research

Explore our scientific papers and see how we turn AI research into dermatological reality. From 3D facial breakthroughs to precision algorithms, we bridge the gap between AI and skin science, leveraging data to reshape the future of skincare.

2026SIDConference

Society for Investigative Dermatology

Prediction of skin biophysical parameters from facial images using deep learning in large-scale population cohorts

Using ~6,000 participants across three independent cohorts, we developed and externally validated machine learning models to predict multidimensional skin phenotypes from facial images.

Authors: Fudi Wang, Tianzi Liu, Siying Fu, Zhiyang Li, Sijia Wang

2025JIDJournal

Journal of Investigative Dermatology

GWASs of the Nasolabial Fold Identified Variants Related to Genes that Also Affect Facial Morphology

The nasolabial fold (NLF) is a prominent dermatological phenotype of the aging midface. Previous anatomical studies have clarified that the NLF is potentially induced by the aging changes in the superficial musculoaponeurotic system architecture, cutaneous ligament, midface musculature and fat compartments, and craniofacial skeleton.

Authors: F. Wang, Y. Zhao, X. Hu, R. Ye, L. Du, Z. Li, S. Wang

2025SIDConference

Society for Investigative Dermatology

Evaluation of imaging-based methods for facial aging detection

Quantifying facial aging is essential in dermatology for studying age-related changes and assessing the effectiveness of skincare products. However, facial aging detection remains challenging due to the absence of standardized benchmarks and unified testing protocols, making it difficult to compare different methods fairly.

Authors: F. Wang, B. Chen, Z. Li

2025IFSCCConference

International Federation of Societies of Cosmetic Chemists

Deep Learning Analysis of Perceived Facial Aging and Influential Features Across Evaluator Groups

Facial aging has long been recognized as an important biomarker of aging and overall health. It is closely linked to numerous age-related diseases, including cardiovascular conditions, metabolic disorders, and neurodegenerative syndromes. As a visible and socially relevant indicator, facial aging has received sustained attention from both scientific communities and the public.

Authors: Fudi Wang, Siying Fu, Baolin Chen, Zhiyang Li, Eagle Lee, Sijia Wang

2025JCDJournal

Journal of Cosmetic Dermatology

Transdermal Delivery of Baicalin Based on Bio-Vesicles and Its Efficacy in Antiaging of the Skin

To develop a stable and efficient delivery system for baicalin, a flavonoid with potential antioxidant and antiaging properties, to overcome its limitations in solubility, stability, and skin permeability.

Authors: Liang Chen, Fudi Wang, Xiaoyun Hu, Nihong Li, Ying Gao, Fengfeng Xue, Ling Xie, Min Xie

2024SIDConference

Society for Investigative Dermatology

Identifying Facial Regions and Aging Features Associated with Perceived Age: A Deep Learning-Based Facial Aging Assessment Method (2024)

Facial aging features manifest with considerable inter-individual variability, leading some individuals to appear younger while others appear older. Classic experiments on perceived age rely on human assessment, which demands significant human resources. In this study, we assembled 160 evaluators to assess the perceived age of 3,186 subjects' faces.

Authors: Fudi Wang, and 7 Others

2023ISIDConference

International Society for Investigative Dermatology

Identification the inflection points of wrinkle types in a large-scale population study of 431,321 subjects

Using AI-based skin analysis on a dataset of 431,321 subjects, this study identifies critical age inflection points at which different wrinkle types begin to accelerate. Our large-scale population analysis provides actionable benchmarks for age-specific skincare product development and clinical intervention timing.

Authors: Fudi Wang, Wen Sha, Siying Fu, Xiaoxue Mo, Xinyi Fu, Sijia Wang

2022ISBSConference

International Society for Biophysics and Imaging of the Skin

Quantifying facial skin aging signs by deep learning-based algorithm (2022)

We present a deep learning algorithm capable of quantifying multiple facial skin aging signs simultaneously from a single photograph. The model achieves dermatologist-level accuracy across key indicators including wrinkles, pigmentation, and skin texture, demonstrating the potential of AI-powered tools for objective skin assessment.

Authors: Sijia Wang

2022SIDConference

Society for Investigative Dermatology

Genome-wide association study of the nasolabial fold identified novel variants associated with facial morphology (2022)

This preliminary genome-wide association study explores the genetic basis of nasolabial fold variation, identifying candidate loci associated with fold depth and morphology. The findings lay groundwork for understanding how genetic factors influence visible facial aging and support the development of genetically informed skincare solutions.

Authors: Fudi Wang, Yuepu Zhao, Siyuan Du, Jiarui Li, Xiaoyun Hu, Zhiyang Li

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